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Azelaic Acid CAS 123-99-9 - High-Quality Chemical from China Suppliers and Factory
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Chemical Name: Azelaic acid
CAS No.: 123-99-9
Molecular Formula: C9H16O4
Molecular Structure:
Molecular Weight: 188.22
Appearance: Crystalline powder
Sample: Free samples available upon request
Key Properties: Azelaic acid features a melting point of approximately 106°C and a boiling point of 286°C at 100 mmHg. This compound is slightly soluble in cold water (about 2.4 g/L at 20°C) and freely soluble in hot water, ethanol, propylene glycol, and ethyl acetate. It is chemically stable and exhibits resistance to oxidation and decomposition. Additionally, azelaic acid demonstrates typical reactions associated with dibasic carboxylic acids, including salt formation and esterification.
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Typical Properties
| Item | Specifications |
| Appearance | Crystalline powder |
| Moisture | ≤0.2% |
| Assay | ≥98% |
| Acid value | 585–610 |
| Melting point | 105–110℃ |
| Particle size | ≥60 mesh |
| Plumbum | ≤1 ppm |
| Arsenic | ≤1 ppm |
| Chromium | ≤1 ppm |
| Color | ≥95% |
| Color | ≥99% |
Application
1. Dermatology / Skincare
Acne Treatment
Inhibits Cutibacterium acnes (formerly P. acnes), regulates follicular keratinization, and exerts anti-inflammatory effects. Common formulations include 15% gel and 20% cream; recommended for topical use by the Chinese Guidelines for Acne Treatment.
Whitening & Mark Fading
Selectively inhibits tyrosinase in abnormal melanocytes to fade acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Its irritation potential is significantly lower than that of tretinoin or high-concentration AHAs.
Oil Control & Soothing
Inhibits 5α-reductase to reduce sebum secretion. Suitable for oily, acne-prone skin and as adjunctive care for rosacea.
Common Dosage Forms
Gels, creams, moisturizers, serums, and masks.
10%: Daily skincare (suitable for sensitive skin)
15%: Mainstay for acne treatment
20%: Pharmaceutical grade (requires tolerance building)
2. Industrial Chemical Sector
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Plasticizers
Synthesis of Dioctyl Azelate (DOZ), Diisooctyl Azelate, etc. Used in PVC and rubber, offering excellent heat resistance, cold resistance, and electrical insulation; suitable for products in low-temperature environments.
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Lubricants / Synthetic Oils
Used as components for precision instruments and aviation hydraulic fluids.
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Coatings / Resins
Modified polyesters and alkyd resins to improve coating flexibility and weatherability.
3. Other Applications
Feed additives, electroplating brighteners, polymer crosslinking agents, etc.
Application Areas
1. Hair Care Industry (Core Application)
Cold Wave Lotions / Perm Solutions: Softens hair keratin and reshapes disulfide bonds to achieve permanent curling; serves as the core reducing agent in cold perms.
Hair Straightening Creams / Relaxers: Cleaves disulfide bonds to soften hair, working in conjunction with neutralizers to achieve permanent straightening.
Depilatory Creams / Lotions: Softens body hair keratin to facilitate easy removal; the preferred choice for mild depilatory products.
Perming / Straightening: Recommended concentration 5%–15%
Depilatory use: Recommended concentration 2%–8%
2. Industrial & Other Fields
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Metal Corrosion Inhibition
Forms a protective FeS film in high-temperature brine/completion fluids to inhibit carbon steel corrosion (140–200℃).
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Chemical Analysis
Used as a masking agent and reducing agent for photometric determination of ions such as iron, aluminum, silver, and tin.
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Material Modification
Serves as a thiolating agent for the preparation of adsorption materials and functional polymers.
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Electronic Cleaning
Acts as an auxiliary agent for metal surface treatment and cleaning.
Package
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Packaging
25kg fiber drums / paper bags (lined with PE bag)
Storage
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Storage Conditions
Store in a well-ventilated, cool, and dry place; keep separate from oxidizing agents.
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Frequently Asked Questions (FAQ)
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What is the recommended concentration of this product for acne treatment?
For acne treatment, a 15% formulation (gel or cream) is the most commonly used concentration and is recommended by the Chinese Guidelines for Acne Treatment. A 20% pharmaceutical-grade concentration is available for more intensive treatment but requires a tolerance-building period. For daily skincare maintenance, a 10% concentration is suitable, especially for sensitive skin.
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How does this product help with skin whitening and hyperpigmentation?
It selectively inhibits tyrosinase activity in abnormal melanocytes, which reduces melanin production and helps fade acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Compared to tretinoin or high-concentration AHAs, it has a significantly lower irritation potential, making it more suitable for sensitive or reactive skin types.
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What industrial applications does this product have?
In the industrial sector, it is widely used as a plasticizer precursor (e.g., for Dioctyl Azelate used in PVC and rubber), as a component in lubricants and synthetic oils for precision instruments and aviation hydraulic fluids, and as a modifier for polyester and alkyd resin coatings to improve flexibility and weatherability. It is also used as feed additives, electroplating brighteners, and polymer crosslinking agents.
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What concentration is recommended for use in hair perming and depilatory products?
For perming and hair straightening applications, a concentration of 5%–15% is recommended. It works by softening hair keratin and reshaping or cleaving disulfide bonds. For depilatory creams and lotions, a lower concentration of 2%–8% is recommended to ensure effective but gentle hair removal.
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What are the packaging specifications and storage requirements?
The product is packaged in 25kg fiber drums or paper bags, each lined with a PE (polyethylene) inner bag to protect against moisture. For storage, it should be kept in a well-ventilated, cool, and dry environment. It must be stored separately from oxidizing agents to prevent degradation or safety hazards.
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What are the key quality specifications of this product?
The product appears as a crystalline powder with a moisture content of ≤0.2% and an assay of ≥98%. Its acid value ranges from 585–610, with a melting point of 105–110℃ and a particle size of ≥60 mesh. Heavy metal content is strictly controlled, with Plumbum, Arsenic, and Chromium each at ≤1 ppm, ensuring high purity suitable for both cosmetic and industrial applications.