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Azelaic Acid CAS 123-99-9 - High-Quality Chemical from China Suppliers and Factory
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Chemical Name: Azelaic Acid
CAS No.: 123-99-9
Molecular Formula: C9H16O4
Molecular Weight: 188.22
Appearance: Crystalline Powder
Sample: Free samples are available for clients.
Key Properties: Azelaic acid has a melting point of approximately 106°C and a boiling point of 286°C (at 100 mmHg). It is slightly soluble in cold water (around 2.4 g/L at 20°C) but freely soluble in hot water, ethanol, propylene glycol, and ethyl acetate. This compound is chemically stable and demonstrates resistance to oxidation and decomposition. Azelaic acid exhibits the common reactions of dibasic carboxylic acids, including salt formation and esterification.
,As a trusted manufacturer in China, we are dedicated to providing high-quality Azelaic acid. Our factory ensures the production of top-tier chemical substances, making us a reliable supplier for your chemical needs.
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Typical Properties
| Item | Specifications |
| Appearance | Crystalline powder |
| Moisture | ≤0.2% |
| Assay | ≥98% |
| Acid value | 585–610 |
| Melting point | 105–110℃ |
| Particle size | ≥60 mesh |
| Plumbum | ≤1 ppm |
| Arsenic | ≤1 ppm |
| Chromium | ≤1 ppm |
| Color | ≥95% |
| Color | ≥99% |
Application
1
Dermatology / Skincare
Acne Treatment
Inhibits Cutibacterium acnes (formerly P. acnes), regulates follicular keratinization, and exerts anti-inflammatory effects. Common formulations include 15% gel and 20% cream; recommended for topical use by the Chinese Guidelines for Acne Treatment.
Whitening & Mark Fading
Selectively inhibits tyrosinase in abnormal melanocytes to fade acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Its irritation potential is significantly lower than that of tretinoin or high-concentration AHAs.
Oil Control & Soothing
Inhibits 5α-reductase to reduce sebum secretion. Suitable for oily, acne-prone skin and as adjunctive care for rosacea.
Common Dosage Forms
Gels, creams, moisturizers, serums, and masks.
10%
Daily skincare (suitable for sensitive skin)
15%
Mainstay for acne treatment
20%
Pharmaceutical grade (requires tolerance building)
2
Industrial Chemical Sector
- Plasticizers: Synthesis of Dioctyl Azelate (DOZ), Diisooctyl Azelate, etc. Used in PVC and rubber, offering excellent heat resistance, cold resistance, and electrical insulation properties; suitable for products in low-temperature environments.
- Lubricants / Synthetic Oils: Used as components for precision instruments and aviation hydraulic fluids.
- Coatings / Resins: Modified polyesters and alkyd resins to improve coating flexibility and weatherability.
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Other Applications
Feed additives, electroplating brighteners, polymer crosslinking agents, etc.
Application Areas
1
Hair Care Industry (Core Application)
- Cold Wave Lotions / Perm Solutions: Softens hair keratin and reshapes disulfide bonds to achieve permanent curling; serves as the core reducing agent in cold perms.
- Hair Straightening Creams / Relaxers: Cleaves disulfide bonds to soften hair, working in conjunction with neutralizers to achieve permanent straightening.
- Depilatory Creams / Lotions: Softens body hair keratin to facilitate easy removal; the preferred choice for mild depilatory products.
Recommended Concentration:
5%–15% for perming/straightening | 2%–8% for depilatory use
5%–15% for perming/straightening | 2%–8% for depilatory use
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Industrial & Other Fields
- Metal Corrosion Inhibition: Forms a protective FeS film in high-temperature brine/completion fluids to inhibit carbon steel corrosion (140–200℃).
- Chemical Analysis: Used as a masking agent and reducing agent for the photometric determination of ions such as iron, aluminum, silver, and tin.
- Material Modification: Serves as a thiolating agent for the preparation of adsorption materials and functional polymers.
- Electronic Cleaning: Acts as an auxiliary agent for metal surface treatment and cleaning.
Package & Storage
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Package
25kg fiber drums / paper bags (lined with PE bag)
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Storage
Store in a well-ventilated, cool, and dry place; keep separate from oxidizing agents.
Frequently Asked Questions
Q
What is the recommended concentration of this ingredient for acne treatment?For acne treatment, a 15% concentration is the mainstay formulation and is recommended by the Chinese Guidelines for Acne Treatment. A 20% pharmaceutical-grade concentration is also available but requires a tolerance-building period. For daily skincare on sensitive skin, a 10% concentration is more appropriate.
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How does this ingredient help with skin whitening and hyperpigmentation?It selectively inhibits tyrosinase activity in abnormal melanocytes, which helps fade acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Compared to tretinoin or high-concentration AHAs, its irritation potential is significantly lower, making it suitable for a wider range of skin types.
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What are the industrial applications of this product?In the industrial sector, it is used as a plasticizer precursor (e.g., Dioctyl Azelate for PVC and rubber), a lubricant component for precision instruments and aviation hydraulic fluids, and a modifier for polyesters and alkyd resins to improve coating flexibility and weatherability. It is also used as a feed additive, electroplating brightener, and polymer crosslinking agent.
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What concentration is recommended for use in hair perming or straightening products?A concentration of 5%–15% is recommended for perming and straightening applications. For depilatory creams and lotions, a lower concentration of 2%–8% is typically used to soften body hair keratin for easy removal.
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How should this product be packaged and stored?The product is supplied in 25kg fiber drums or paper bags, each lined with a PE (polyethylene) inner bag to protect against moisture. It should be stored in a well-ventilated, cool, and dry environment, and must be kept separate from oxidizing agents to ensure product stability and safety.
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What purity and quality standards does this product meet?The product meets high purity standards with an assay of ≥98% and moisture content of ≤0.2%. Heavy metal content is strictly controlled, with Plumbum, Arsenic, and Chromium all ≤1 ppm. The particle size is ≥60 mesh, melting point is 105–110℃, and acid value is 585–610, ensuring consistent quality for both cosmetic and industrial applications.