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Azelaic Acid CAS 123-99-9 - High-Quality Crystalline Powder from China Suppliers and Factory
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Chemical Name: Azelaic acid
CAS No.: 123-99-9
Molecular Formula: C9H16O4
Molecular Structure:
Molecular Weight: 188.22
Appearance: Crystalline powder
Sample: Free samples available from our China factory
Key Properties: Azelaic acid has a melting point of approximately 106°C and a boiling point of 286°C (at 100 mmHg). It is slightly soluble in cold water (about 2.4 g/L at 20°C) but becomes freely soluble in hot water, ethanol, propylene glycol, and ethyl acetate. This compound demonstrates excellent chemical stability and is resistant to oxidation and decomposition. Azelaic acid exhibits the characteristic reactions of dibasic carboxylic acids, including salt formation and esterification. As trusted suppliers based in China, we offer high-quality Azelaic acid to meet your needs.
,Typical Properties
| Item | Specifications |
| Appearance | Crystalline powder |
| Moisture | ≤0.2% |
| Assay | ≥98% |
| Acid value | 585-610 |
| Melting point | 105-110℃ |
| particle size | ≥60 mesh |
| Plumbum | ≤1 ppm |
| Arsenic | ≤1 ppm |
| chromium | ≤1 ppm |
| Color | ≥ 95% |
| Color | ≥ 99% |
Application
1. Dermatology / Skincare
Acne Treatment
Inhibits Cutibacterium acnes (formerly P. acnes), regulates follicular keratinization, and exerts anti-inflammatory effects. Common formulations include 15% gel and 20% cream; recommended for topical use by the Chinese Guidelines for Acne Treatment.
Whitening & Mark Fading
Selectively inhibits tyrosinase in abnormal melanocytes to fade acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Its irritation potential is significantly lower than that of tretinoin or high-concentration AHAs.
Oil Control & Soothing
Inhibits 5α-reductase to reduce sebum secretion. Suitable for oily, acne-prone skin and as adjunctive care for rosacea.
Common Dosage Forms
Gels, creams, moisturizers, serums, and masks.
- 10%: Daily skincare (suitable for sensitive skin)
- 15%: Mainstay for acne treatment
- 20%: Pharmaceutical grade (requires tolerance building)
2. Industrial Chemical Sector
- Plasticizers: Synthesis of Dioctyl Azelate (DOZ), Diisooctyl Azelate, etc. Used in PVC and rubber, offering excellent heat resistance, cold resistance, and electrical insulation properties; suitable for products in low-temperature environments.
- Lubricants / Synthetic Oils: Used as components for precision instruments and aviation hydraulic fluids.
- Coatings / Resins: Modified polyesters and alkyd resins to improve coating flexibility and weatherability.
3. Other Applications
Feed additives, electroplating brighteners, polymer crosslinking agents, etc.
Application Areas
1. Hair Care Industry (Core Application)
- Cold Wave Lotions / Perm Solutions: Softens hair keratin and reshapes disulfide bonds to achieve permanent curling; serves as the core reducing agent in cold perms.
- Hair Straightening Creams / Relaxers: Cleaves disulfide bonds to soften hair, working in conjunction with neutralizers to achieve permanent straightening.
- Depilatory Creams / Lotions: Softens body hair keratin to facilitate easy removal; the preferred choice for mild depilatory products.
- Recommended Concentration: 5%–15% for perming/straightening; 2%–8% for depilatory use.
2. Industrial & Other Fields
- Metal Corrosion Inhibition: Forms a protective FeS film in high-temperature brine/completion fluids to inhibit carbon steel corrosion (140–200℃).
- Chemical Analysis: Used as a masking agent and reducing agent for the photometric determination of ions such as iron, aluminum, silver, and tin.
- Material Modification: Serves as a thiolating agent for the preparation of adsorption materials and functional polymers.
- Electronic Cleaning: Acts as an auxiliary agent for metal surface treatment and cleaning.
Package
25kg fiber drums / paper bags (lined with PE bag)
Storage
Store in a well-ventilated, cool, and dry place; keep separate from oxidizing agents.
Frequently Asked Questions (FAQ)
What are the main specifications of this crystalline powder?
This product features an assay of ≥98%, moisture levels ≤0.2%, an acid value of 585-610, and a melting point of 105-110℃. The particle size is ≥60 mesh, and heavy metals (Plumbum, Arsenic, Chromium) are strictly controlled at ≤1 ppm.
How is this product used in dermatology and skincare formulations?
It is widely used for acne treatment (typically in 15% gel or 20% cream formulations), whitening & mark fading (by inhibiting tyrosinase to treat melasma and PIH), and oil control. A 10% concentration is recommended for daily use on sensitive skin.
What role does this chemical play in the hair care industry?
It is a core reducing agent in cold wave lotions and perm solutions, softening hair keratin and reshaping disulfide bonds for curling. It is also used in hair straightening creams (5%–15% concentration) and depilatory creams (2%–8% concentration).
Can this chemical be used for industrial and mechanical applications?
Yes. In the industrial chemical sector, it is used to synthesize plasticizers (like DOZ) for PVC and rubber, as a component in synthetic oils and aviation lubricants, and in coatings/resins. It also serves as a metal corrosion inhibitor in high-temperature environments.
What are the recommended packaging and storage conditions?
The product is packaged in 25kg fiber drums or paper bags lined with PE bags. It must be stored in a well-ventilated, cool, and dry place, completely separated from oxidizing agents to prevent degradation or hazards.