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Azelaic Acid CAS 123-99-9 - High-Quality Supplier from China | Reliable Factory Products
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Chemical Name: Azelaic Acid
, CAS No.: 123-99-9
, Molecular Formula: C9H16O4
Molecular Weight: 188.22
, Appearance: White crystalline powder
, Sample: Free samples available for evaluation
Key Properties: Azelaic acid has a melting point of approximately 106°C and a boiling point of 286°C (at 100 mmHg). It is slightly soluble in cold water (about 2.4 g/L at 20°C), but freely soluble in hot water, ethanol, propylene glycol, and ethyl acetate. This compound is chemically stable, resistant to oxidation and decomposition, and exhibits typical reactions of dibasic carboxylic acids, including salt formation and esterification.
,As a leading manufacturer and suppliers of Azelaic acid in China, our factory ensures high-quality production standards and reliable supply chains, catering to various industries seeking effective chemical solutions.
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Typical Properties
| Item | Specifications |
| Appearance | Crystalline powder |
| Moisture | ≤0.2% |
| Assay | ≥98% |
| Acid value | 585–610 |
| Melting point | 105–110℃ |
| Particle size | ≥60 mesh |
| Plumbum | ≤1 ppm |
| Arsenic | ≤1 ppm |
| Chromium | ≤1 ppm |
| Color | ≥95% |
| Color | ≥99% |
Application
Acne Treatment
Inhibits Cutibacterium acnes (formerly P. acnes), regulates follicular keratinization, and exerts anti-inflammatory effects. Common formulations include 15% gel and 20% cream; recommended for topical use by the Chinese Guidelines for Acne Treatment.
Whitening & Mark Fading
Selectively inhibits tyrosinase in abnormal melanocytes to fade acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Its irritation potential is significantly lower than that of tretinoin or high-concentration AHAs.
Oil Control & Soothing
Inhibits 5α-reductase to reduce sebum secretion. Suitable for oily, acne-prone skin and as adjunctive care for rosacea.
Common Dosage Forms
Gels, creams, moisturizers, serums, and masks.
10%
Daily skincare (suitable for sensitive skin)
15%
Mainstay for acne treatment
20%
Pharmaceutical grade (requires tolerance building)
●Plasticizers: Synthesis of Dioctyl Azelate (DOZ), Diisooctyl Azelate, etc. Used in PVC and rubber, offering excellent heat resistance, cold resistance, and electrical insulation properties; suitable for products in low-temperature environments.
●Lubricants / Synthetic Oils: Used as components for precision instruments and aviation hydraulic fluids.
●Coatings / Resins: Modified polyesters and alkyd resins to improve coating flexibility and weatherability.
Feed additives, electroplating brighteners, polymer crosslinking agents, etc.
Application Areas
●Cold Wave Lotions / Perm Solutions: Softens hair keratin and reshapes disulfide bonds to achieve permanent curling; serves as the core reducing agent in cold perms.
●Hair Straightening Creams / Relaxers: Cleaves disulfide bonds to soften hair, working in conjunction with neutralizers to achieve permanent straightening.
●Depilatory Creams / Lotions: Softens body hair keratin to facilitate easy removal; the preferred choice for mild depilatory products.
●Recommended Concentration: 5%–15% for perming/straightening; 2%–8% for depilatory use.
●Metal Corrosion Inhibition: Forms a protective FeS film in high-temperature brine/completion fluids to inhibit carbon steel corrosion (140–200℃).
●Chemical Analysis: Used as a masking agent and reducing agent for the photometric determination of ions such as iron, aluminum, silver, and tin.
●Material Modification: Serves as a thiolating agent for the preparation of adsorption materials and functional polymers.
●Electronic Cleaning: Acts as an auxiliary agent for metal surface treatment and cleaning.
Package & Storage
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Package
25kg fiber drums / paper bags (lined with PE bag)
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Storage
Store in a well-ventilated, cool, and dry place; keep separate from oxidizing agents.
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Frequently Asked Questions
Q1 What is the recommended concentration of azelaic acid for acne treatment?
For acne treatment, a 15% formulation (gel or cream) is the most commonly recommended concentration and is recognized by the Chinese Guidelines for Acne Treatment. A 20% pharmaceutical-grade concentration is also available but requires a gradual tolerance-building process. For daily sensitive skincare, a 10% concentration is more suitable.
Q2 How does azelaic acid help with skin whitening and hyperpigmentation?
Azelaic acid selectively inhibits tyrosinase activity in abnormal melanocytes, which reduces the overproduction of melanin. This makes it effective for fading acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Compared to tretinoin or high-concentration AHAs, it carries a significantly lower risk of irritation.
Q3 What are the industrial uses of azelaic acid?
In the industrial sector, azelaic acid is primarily used in the synthesis of plasticizers such as Dioctyl Azelate (DOZ) for PVC and rubber applications, as a component in lubricants and aviation hydraulic fluids, and in the modification of polyesters and alkyd resins to enhance coating flexibility and weatherability. It is also used as a feed additive, electroplating brightener, and polymer crosslinking agent.
Q4 How is azelaic acid used in hair care products?
Azelaic acid plays a key role in hair care as a core reducing agent in cold perm solutions (5%–15%) to reshape disulfide bonds for permanent curling, in hair straightening creams/relaxers to achieve permanent straightening, and in depilatory creams (2%–8%) to soften body hair for easy removal. It is preferred for mild depilatory formulations.
Q5 What are the storage and packaging requirements for azelaic acid?
Azelaic acid should be stored in a well-ventilated, cool, and dry environment, and must be kept separate from oxidizing agents to maintain its stability and quality. It is packaged in 25kg fiber drums or paper bags, each lined with a PE (polyethylene) inner bag to protect against moisture and contamination.
Q6 What is the purity and physical form of this azelaic acid product?
This azelaic acid product appears as a crystalline powder with an assay of ≥98% purity and moisture content of ≤0.2%. It has a melting point of 105–110℃, a particle size of ≥60 mesh, and heavy metal content (lead, arsenic, chromium) each controlled to ≤1 ppm, ensuring high quality suitable for both cosmetic and industrial applications.