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Azelaic Acid CAS 123-99-9 - Quality Crystalline Powder from China Suppliers & Factory
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Chemical Name: Azelaic Acid
, CAS No.: 123-99-9
, Molecular Formula: C9H16O4
, Molecular Structure:
Molecular Weight: 188.22
, Appearance: Crystalline powder
, Sample: Free samples are available
Key Properties: Azelaic Acid features a melting point of approximately 106°C and a boiling point of 286°C (at 100 mmHg). It is slightly soluble in cold water (around 2.4 g/L at 20°C) but is freely soluble in hot water, ethanol, propylene glycol, and ethyl acetate. This compound is chemically stable, resistant to oxidation and decomposition, and exhibits the typical reactions of dibasic carboxylic acids, including salt formation and esterification.
,As a leading supplier from China, our factory ensures the highest quality of Azelaic Acid, making it an ideal choice for various applications in the chemical industry.
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Typical Properties
| Item | Specifications |
| Appearance | Crystalline powder |
| Moisture | ≤0.2% |
| Assay | ≥98% |
| Acid value | 585–610 |
| Melting point | 105–110℃ |
| Particle size | ≥60 mesh |
| Plumbum | ≤1 ppm |
| Arsenic | ≤1 ppm |
| Chromium | ≤1 ppm |
| Color | ≥ 95% |
| Color | ≥ 99% |
Application
1
Dermatology / Skincare
Acne Treatment
Inhibits Cutibacterium acnes (formerly P. acnes), regulates follicular keratinization, and exerts anti-inflammatory effects. Common formulations include 15% gel and 20% cream; recommended for topical use by the Chinese Guidelines for Acne Treatment.
Whitening & Mark Fading
Selectively inhibits tyrosinase in abnormal melanocytes to fade acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Its irritation potential is significantly lower than that of tretinoin or high-concentration AHAs.
Oil Control & Soothing
Inhibits 5α-reductase to reduce sebum secretion. Suitable for oily, acne-prone skin and as adjunctive care for rosacea.
Common Dosage Forms
Gels, creams, moisturizers, serums, and masks.
10%Daily skincare (suitable for sensitive skin)
15%Mainstay for acne treatment
20%Pharmaceutical grade (requires tolerance building)
2
Industrial Chemical Sector
- Plasticizers: Synthesis of Dioctyl Azelate (DOZ), Diisooctyl Azelate, etc. Used in PVC and rubber, offering excellent heat resistance, cold resistance, and electrical insulation properties; suitable for products in low-temperature environments.
- Lubricants / Synthetic Oils: Used as components for precision instruments and aviation hydraulic fluids.
- Coatings / Resins: Modified polyesters and alkyd resins to improve coating flexibility and weatherability.
3
Other Applications
Feed additives, electroplating brighteners, polymer crosslinking agents, etc.
Application Areas
1
Hair Care Industry (Core Application)
- Cold Wave Lotions / Perm Solutions: Softens hair keratin and reshapes disulfide bonds to achieve permanent curling; serves as the core reducing agent in cold perms.
- Hair Straightening Creams / Relaxers: Cleaves disulfide bonds to soften hair, working in conjunction with neutralizers to achieve permanent straightening.
- Depilatory Creams / Lotions: Softens body hair keratin to facilitate easy removal; the preferred choice for mild depilatory products.
- Recommended Concentration: 5%–15% for perming/straightening; 2%–8% for depilatory use.
2
Industrial & Other Fields
- Metal Corrosion Inhibition: Forms a protective FeS film in high-temperature brine/completion fluids to inhibit carbon steel corrosion (140–200℃).
- Chemical Analysis: Used as a masking agent and reducing agent for the photometric determination of ions such as iron, aluminum, silver, and tin.
- Material Modification: Serves as a thiolating agent for the preparation of adsorption materials and functional polymers.
- Electronic Cleaning: Acts as an auxiliary agent for metal surface treatment and cleaning.
Package & Storage
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Package
25kg fiber drums / paper bags (lined with PE bag)
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Storage
Store in a well-ventilated, cool, and dry place; keep separate from oxidizing agents.
Frequently Asked Questions
QWhat is the recommended concentration for using this product in acne treatment formulations?
For acne treatment, a 15% concentration (gel or cream) is the mainstay formulation and is recommended by the Chinese Guidelines for Acne Treatment. A 10% concentration is suitable for daily skincare, especially for sensitive skin, while a 20% pharmaceutical-grade formulation requires a gradual tolerance-building approach.
QHow does this product help with skin whitening and hyperpigmentation?
It selectively inhibits tyrosinase activity in abnormal melanocytes, effectively fading acne marks, post-inflammatory hyperpigmentation (PIH), and melasma. Compared to tretinoin or high-concentration AHAs, it carries a significantly lower risk of skin irritation, making it suitable for a wider range of skin types.
QWhat concentration is appropriate for hair perming and depilatory applications?
For perming and hair straightening applications, a concentration of 5%–15% is recommended. For depilatory creams and lotions, a lower concentration of 2%–8% is sufficient to soften body hair keratin for easy removal while maintaining a mild profile.
QCan this product be used in industrial applications beyond cosmetics?
Yes. In the industrial sector, it is widely used as a plasticizer (e.g., Dioctyl Azelate for PVC and rubber), a component in lubricants and aviation hydraulic fluids, and as a modifier for polyesters and alkyd resin coatings. Additional applications include feed additives, electroplating brighteners, and polymer crosslinking agents.
QWhat are the storage requirements for this product?
The product should be stored in a well-ventilated, cool, and dry environment. It must be kept separate from oxidizing agents to prevent degradation or hazardous reactions. The standard packaging is 25kg fiber drums or paper bags, each lined with a PE bag for added protection.
QWhat purity and quality standards does this product meet?
The product meets high purity standards with an assay of ≥98% and moisture content of ≤0.2%. Heavy metal content is strictly controlled, with Plumbum, Arsenic, and Chromium all at ≤1 ppm. The melting point is 105–110℃ and the acid value falls within the range of 585–610, ensuring consistent quality for both cosmetic and industrial use.