Tris Base CAS 77-86-1
Chemical Name:Tris Base
CAS No.: 77-86-1
Molecular Formula:C4H11NO3
Molecular Structure:
Molecular Weight:121.14
Appearance:White crystal powder
Sample:Free samples are available
Assay: 99.5%
Typical Properties
|
Item |
Specifications |
|
Content |
99.5%—101.0% |
|
Moisture (by karl fischer) |
≤0.3% |
|
Insolubles |
≤0.005% |
|
PH(5%) |
10.0-11.5 |
|
UV Absorbance (290nm,40%) |
≤0.2 |
|
UV Absorbance (400nm 40%) |
≤0.2 |
|
Heavy metals (as pb) |
≤5ppm |
|
Fe |
≤5ppm |
|
Cl |
≤3ppm |
|
Solubility （1.0M solution in water） |
Immediately soluble yielding a clear haze-free solution free of particulates |
|
Residue on ignition |
≤0.05% |
|
Melting point（℃） |
168.0-172.0 |
|
Appearance |
White crystal powder |
Applications
1.Biological Buffers
Molecular Biology: DNA/RNA extraction, agarose gel electrophoresis (TAE/TBE buffers).
Protein Biochemistry: Enzyme activity assays, protein purification, ELISA, and chromatography eluents.
Cell Culture: Maintains stable pH in culture media, compatible with the physiological pH range of 7–9.
Advantages: No calcium/magnesium precipitation (compared to phosphate buffers), excellent compatibility, and high cost-performance.
2.Pharmaceutical Field
Acid-Base Regulator (Tromethamine): Corrects metabolic/respiratory acidosis; penetrates cell membranes without increasing CO₂ retention.
Pharmaceutical Excipient: pH stabilizer for injections (e.g., Iopromide) and lyophilized preparations.
Pharmaceutical Intermediate: Used in the synthesis of antibacterial drugs, local anesthetics, and contrast agents.
3.Cosmetics & Daily Chemicals
pH Adjuster: Provides gentle pH stabilization for lotions, creams, serums, and shampoos, reducing irritation.
Stabilizer: Improves formulation stability and extends shelf life.
4.Industrial Applications
Coatings / Inks: pH adjuster, dispersant, and anti-settling agent.
Surfactants: Synthesis of non-ionic surfactants and emulsifiers.
Rubber Auxiliaries: Vulcanization accelerator and antioxidant intermediate.
Water Treatment: Heavy metal chelating agent and pH regulator.
Package
25kg/drum
Storage
Store in a cool, dry place; keep sealed and protected from moisture.